Xin / James Guo

Principal Research Scientist at SAIS

AI for Life Sciences · Multimodal Scientific Foundation Models Scientific Agentic AI · Automated Labs for Discovery

About Me

Xin Guo

I am a Principal Research Scientist at the Shanghai Academy of Artificial Intelligence for Science (SAIS), where I work on AI for life sciences and scientific discovery. My research focuses on multi-omics, biological representation learning, scientific foundation models, and AI systems that can support reliable discovery workflows.

Representative work includes FLAG for spatial gene expression prediction, ChromFound for single-cell chromatin accessibility modeling, and SOLD for structure-based RNA design. Before SAIS, I spent eight years at Ant and Alibaba Group building applied AI systems across computer vision, multimodal perception, and foundation models, with earlier research and engineering experience at Sony and Tractable in Europe.

20+ papers
10+ international patents
10+ years in AI

Research Highlights

AI for Life Sciences

Multi-omics, spatial biology, single-cell epigenomics, RNA design, and biological representation learning for scientific discovery.

Multimodal Scientific Foundation Models

Foundation models for heterogeneous scientific data, aligning molecular, omics, imaging, and structured biological signals into reusable representations.

Scientific Agentic AI

Reasoning and tool-using AI systems that plan, call scientific tools, and support reliable discovery workflows.

Automated Labs for Closed-Loop Discovery

AI-driven experimental platforms that connect hypothesis generation, experiment planning, robotic execution, measurement, and feedback.

Selected Publications

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* Equal contribution · Corresponding Author

Agentic AI

Sprint or Delve: A Distribution-Aware Approach to Efficient Reasoning

Zehui Ling, Deshu Chen, Hongwei Zhang, Yifeng Jiao, Xin Guo, Zenglin Xu, Yuan Cheng
IJCAI 2026

Recent News

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🏅 Honored to receive the ICML 2026 Silver Reviewer Award. Grateful for the recognition and for the opportunity to contribute to the research community.
🎉 Two papers accepted: FLAG, on foundation-model-aligned latent diffusion for spatial gene expression prediction, at ICML 2026; and "Sprint or Delve: A Distribution-Aware Approach to Efficient Reasoning" at IJCAI 2026. Congrats to all co-authors!
📚 Two recent works have been published: one in Nature Computational Science on generalizable X-ray tomography restoration, and another in AAAI 2026 focusing on structure-based RNA design using latent diffusion models.
🏅 Honored to be selected for the Shanghai Oriental Talent Program (Young Talent Project). Grateful for the recognition and support from the Shanghai government.
  • Apr. 2024 - Present

    Principal Research Scientist
    SAIS

  • Apr. 2016 - Apr. 2024

    Senior R&D Engineer
    Ant & Alibaba Group

  • Sep. 2012 - Nov. 2015

    MSc in Communication Systems
    EPFL

  • Sep. 2008 - Jun. 2012

    BEng with Honors
    Zhejiang University

Contact

I welcome collaborations in AI for life sciences, multimodal scientific foundation models, scientific agentic AI, and automated labs for closed-loop discovery, including multi-omics, spatial biology, RNA design, and tool-using AI systems.

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