Publications

* Equal contribution · ✉ Corresponding Author

AI4Biomedicine at SAIS

  1. PAST: A multimodal single-cell foundation model for histopathology and spatial transcriptomics in cancer

    Changchun Yang, Haoyang Li, Yushuai Wu, Yilan Zhang, Yifeng Jiao, Yu Zhang, Rihan Huang, Qiangcheng Zeng, Yuan Cheng, Xin Guo✉, Xin Gao, Yuan Qi
    Cell Systems, 2026 (accepted in principle)
    Paper Code

  2. GOLD: Geometric Optimized Latent Diffusion for Structure-Aware RNA Inverse Folding

    Qi Si, Xuyang Liu, Penglei Wang, Shuo Su, Limei Han, Mengzhu Li, Xin Guo✉, Yuan Qi, Yuan Cheng
    NeurIPS 2026 (Spotlight)
    Paper

  3. Nüwa.RNA: An RNA Foundation Model for Unified Representation with Deep Structure Infusion

    Kun Huang, Jiyang Li, Xin Guo✉, Limei Han, Yuan Cheng
    NeurIPS 2026
    Paper

  4. TRACE-GRPO: Teacher-Refined Advantage Credit Estimation for Long-Horizon Agentic RL

    Yuchen Liu, Tianchu Yao, Deshu Chen, Yinghao Zhang, Xigui Li, Zehui Ling, Xin Guo, Yuan Cheng, Chao Qu, Lintao Ma, Yuan Qi
    EMNLP 2026
    Code

  5. Topological-Aware Regularization for Semi-Supervised Intracranial Aneurysm Vessel Segmentation

    Feiyang Xiao, Yichi Zhang, Xigui Li, Yuanye Zhou, Chen Jiang, Xin Guo, Limei Han, Yuxin Li, Fengping Zhu, Yuan Cheng
    MIDL 2026
    Paper Code

  6. Ophora: A Large-Scale Data-Driven Text-Guided Ophthalmic Surgical Video Generation Model

    Wei Li, Ming Hu, Guoan Wang, Lihao Liu, Kaijing Zhou, Junzhi Ning, Xin Guo, Zongyuan Ge, Lixu Gu, Junjun He
    MICCAI 2025 (Oral)
    Paper Code

  8. Efficient Network Automatic Relevance Determination

    Hongwei Zhang, Ziqi Ye, Xinyuan Wang, Xin Guo, Zenglin Xu, Yuan Cheng, Zixin Hu, Yuan Qi
    ICML 2025
    Paper

  9. Structure-aware Semantic Discrepancy and Consistency for 3D Medical Image Self-supervised Learning

    Tan Pan, Zhaorui Tan, Kaiyu Guo, Dongli Xu, Weidi Xu, Chen Jiang, Xin Guo, Yuan Qi, Yuan Cheng
    ICCV 2025
    Paper Code

  10. Towards a Universal 3D Medical Multi-modality Generalization via Learning Personalized Invariant Representation

    Zhaorui Tan, Xi Yang, Tan Pan, Tianyi Liu, Chen Jiang, Xin Guo, Qiufeng Wang, Anh Nguyen, Yuan Qi, Kaizhu Huang, Yuan Cheng
    ICCV 2025
    Paper Code

  11. SCRIPT: Predicting Single-Cell Long-Range Cis-Regulation Based on Pretrained Graph Attention Networks

    Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian
    Advanced Science, 2025
    Paper Code

  12. ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data

    Yifeng Jiao, Yuchen Liu, Yu Zhang, Xin Guo✉, Yushuai Wu, Chen Jiang, Jiyang Li, Hongwei Zhang, Limei Han, Xin Gao, Yuan Qi, Yuan Cheng
    NeurIPS 2025
    Paper Code

  13. Minimal Semantic Sufficiency Meets Unsupervised Domain Generalization

    Tan Pan, Kaiyu Guo, Dongli Xu, Zhaorui Tan, Chen Jiang, Deshu Chen, Xin Guo, Brian C. Lovell, Limei Han, Yuan Cheng, Mahsa Baktashmotlagh
    NeurIPS 2025
    Paper

  14. Structure-based RNA Design by Step-wise Optimization of Latent Diffusion Model

    Qi Si, Xuyang Liu, Penglei Wang, Xin Guo✉, Yuan Qi, Yuan Cheng
    AAAI 2026
    Paper Code

  15. HorusEye: a self-supervised foundation model for generalizable X-ray tomography restoration

    Yuetan Chu, Longxi Zhou, Gongning Luo, Kai Kang, Suyu Dong, Zhongyi Han, Lianming Wu, Xianglin Meng, Changchun Yang, Xin Guo, Yuan Cheng, Yuan Qi, Xin Liu, Dexuan Xie, Yue Li, Ricardo Henao, Xigang Xiao, Shaodong Cao, Gianluca Setti, Zhaowen Qiu, Xin Gao
    Nature Computational Science, 2026
    Paper Code

  16. FLAG: Foundation model representation with Latent diffusion Alignment via Graph for spatial gene expression prediction

    Qi Si, Penglei Wang, Yushuai Wu, Yifeng Jiao, Xuyang Liu, Xin Guo✉, Yuan Qi, Yuan Cheng
    ICML 2026
    Paper Code

  17. Sprint or Delve: A Distribution-Aware Approach to Efficient Reasoning

    Zehui Ling, Deshu Chen, Hongwei Zhang, Yifeng Jiao, Xin Guo, Zenglin Xu, Yuan Cheng
    IJCAI 2026
    Paper

亿亩田 with Ant & MYBank & Wuhan University

  1. Simultaneously Short- and Long-Term Temporal Modeling for Semi-Supervised Video Semantic Segmentation

    Jiangwei Lao, Weixiang Hong, Xin Guo, Yingying Zhang, Jian Wang, Jingdong Chen, Wei Chu
    CVPR 2023
    Paper

  2. SkySense: A Multi-Modal Remote Sensing Foundation Model Towards Universal Interpretation for Earth Observation Imagery

    Xin Guo*, Jiangwei Lao*, Bo Dang*, Yingying Zhang, Lei Yu, Lixiang Ru, Liheng Zhong, Ziyuan Huang, Kang Wu, Dingxiang Hu, Huimei He, Jian Wang, Jingdong Chen, Ming Yang, Yongjun Zhang, Yansheng Li
    CVPR 2024
    Paper Code

  3. POA: Pre-training Once for Models of All Sizes

    Yingying Zhang, Xin Guo, Jiangwei Lao, Lei Yu, Lixiang Ru, Jian Wang, Guo Ye, Huimei He, Jingdong Chen, Ming Yang
    ECCV 2024
    Paper Code

  4. Parameter-Efficient Complementary Expert Learning for Long-Tailed Visual Recognition

    Lixiang Ru, Xin Guo, Lei Yu, Yingying Zhang, Jiangwei Lao, Jian Wang, Jingdong Chen, Yansheng Li, Ming Yang
    ACM Multimedia 2024
    Paper

  5. Unleashing the potential of remote sensing foundation models via bridging data and computility islands

    Yansheng Li, Jieyi Tan, Bo Dang, Mang Ye, Sergey A Bartalev, Shinkarenko Stanislav, Linlin Wang, Yingying Zhang, Lixiang Ru, Xin Guo, Liangqi Yuan, Lei Yu, Jingdong Chen, Ming Yang, José Marcato Junior, Yongjun Zhang
    The Innovation, 2025
    Paper

  6. Learning to reason over multi-granularity knowledge graph for zero-shot urban land-use mapping

    Yansheng Li, Yu Wang, Lei Yu, Bo Dang, Gang Xu, Zhenyu Zhong, Yuning Wu, Xin Guo, Kang Wu, Zheng Li, Linlin Wang, Jian Wang, Jingdong Chen, Ming Yang, Yongjun Zhang
    Remote Sensing of Environment, 2025
    Paper

定损宝 at Ant Group

  1. Automatic Car Damage Assessment System: Reading and Understanding Videos as Professional Insurance Inspectors

    Wei Zhang, Yuan Cheng, Xin Guo, Qingpei Guo, Jian Wang, Qing Wang, Chen Jiang, Meng Wang, Furong Xu, Wei Chu
    AAAI 2020
    Paper

Blind source separation at Sony AI